Tocris/W-84 dibromide/0532/10/10 mg-蚂蚁淘生物

Description: Stabilizer of cholinergic antagonist-receptor complexes Chemical Name: Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Increases the protective effect of atropine against organophosphate poisoning.

Technical Data

M. Wt	708.53
Formula	C₃₂H₄₄Br₂N₄O₄
Storage	Store at RT
CAS Number	21093-51-6
PubChem ID	167961
InChI Key	DZRJZDQAGMZGGA-UHFFFAOYSA-L
Smiles	O=C1N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN(C(C4=C3C=CC=C4)=O)C3=O)C(C2=C1C=CC=C2)=O.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO

7.08

Preparing Stock Solutions

The following data is based on the product molecular weight 708.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	1.41 mL	7.06 mL	14.11 mL
5 mM	0.28 mL	1.41 mL	2.82 mL
10 mM	0.14 mL	0.71 mL	1.41 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Jepsen et al (1988) Allosteric stabilisation of [³H]-N-methylscopolamine binding in guinea pig myocardium by an antidote against organophosphate intoxication. Pharmacol.Toxicol. 63 163 PMID: 3054859

Mitchelson (1975) Antimuscarinic action of an alkane-bis ammonium compound alone and in combination with (+)-bensetimide. Eur.J.Pharmacol. 33 237 PMID: 1242377

Mohr et al (1992) Equipotent allosteric effect of W84 on [³H]-NMS binding to cardiac muscarinic receptors from guinea-pig, rat and pig. Pharmacol.Toxicol. 70 198 PMID: 1579545

Keywords: W-84 dibromide, supplier, antagonists-receptor, complex, stabilizer, Muscarinic, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, Non-selective, Muscarinics, Tocris Bioscience