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Heat Shock 40 kDa Protein; Hdj1; HSPF1; DNAJ1; DNAJB

Monoclonal Antibody

419401.0

Mouse IgG2b

Recombinant human HSP40.

Western Blot (0.5µg/ml)

HumanMouseRat

Recognizes human, mouse and rat HSP40.

Protein A or G purified.

Liquid. In PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.

Manufactured by Boston Biochem

BLUE ICE

+4°C

-20°C

Aliquot to avoid freeze/thaw cycles.

Stable for at least 1 year after receipt when stored at -20°C.

No

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Heat shock protein 40 kDa (HSP40) is the human homologue of the bacterial DnaJ heat shock protein. HSP40, also known as HSPF1 and DnaJ Homolog subfamily B member 1 (DNAJB1), is a 340 amino acid, 40 kDa member of the heat shock protein family. Heat shock proteins (HSPs) are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperones, facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. HSP40 is a stress inducible chaperone that co-localizes with HSP70 and can bind unfolded proteins and prevent protein denaturation and aggregation. The conserved amino terminal J domain can interact with HSP70 and stimulate its ATPase activity.