Product overview

• NameNSC 33994
• Short descriptionPotent, selective JAK2 inhibitor
• Biological descriptionPotent and selective JAK2 inhibitor (IC₅₀ = 60 nM). Shows anti-neoplastic actions.
• Alternative namesG6
• Biological actionInhibitor
• Purity>98%
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Properties

• Chemical nameE-4,4-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
• Molecular Weight438.65
• Chemical structure
• Molecular FormulaC₂₈H₄₂N₂O₂
• CAS Number82058-16-0

Storing and Using Your Product

• Storage instructions-20°C
• Solubility overviewsoluble in DMSO (5mM, gentle warming) or ethanol (10mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NSC 33994

• Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.

  Kiss R et al (2009)Bioorg Med Chem Lett 19(13) : 3598-601. PubMedID: 19447617

• The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.

  Baskin R et al (2014)PLoS One 9(8) : e105568. PubMedID: 25162558

• The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.

  Kirabo A et al (2011)Neoplasia 13(11) : 1058-68. PubMedID: 22131881