Hello Bio/NSC 33994/HB1430/50mg
Product overview
- NameNSC 33994
- Short descriptionPotent, selective JAK2 inhibitor
- Biological descriptionPotent and selective JAK2 inhibitor (IC50 = 60 nM). Shows anti-neoplastic actions.
- Alternative namesG6
- Biological actionInhibitor
- Purity>98%
- Our products in actionSubmit Your Citation Now
Properties
- Chemical nameE-4,4-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
- Molecular Weight438.65
- Chemical structure

- Molecular FormulaC28H42N2O2
- CAS Number82058-16-0
Storing and Using Your Product
- Storage instructions-20°C
- Solubility overviewsoluble in DMSO (5mM, gentle warming) or ethanol (10mM)
- ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for NSC 33994
Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.
Kiss R et al (2009)Bioorg Med Chem Lett 19(13) : 3598-601. PubMedID: 19447617The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.
Baskin R et al (2014)PLoS One 9(8) : e105568. PubMedID: 25162558The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.
Kirabo A et al (2011)Neoplasia 13(11) : 1058-68. PubMedID: 22131881