tech_banner
Hello Bio/NSC 33994/HB1430/50mg

Product overview

  • NameNSC 33994
  • Short descriptionPotent, selective JAK2 inhibitor
  • Biological descriptionPotent and selective JAK2 inhibitor (IC50 = 60 nM). Shows anti-neoplastic actions.
  • Alternative namesG6
  • Biological actionInhibitor
  • Purity>98%
  • Our products in actionSubmit Your Citation Now

Properties

  • Chemical nameE-4,4-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
  • Molecular Weight438.65
  • Chemical structure\"NSC
  • Molecular FormulaC28H42N2O2
  • CAS Number82058-16-0

Storing and Using Your Product

  • Storage instructions-20°C
  • Solubility overviewsoluble in DMSO (5mM, gentle warming) or ethanol (10mM)
  • ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for NSC 33994

  • Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.

    Kiss R et al (2009)Bioorg Med Chem Lett 19(13) : 3598-601. PubMedID: 19447617
  • The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.

    Baskin R et al (2014)PLoS One 9(8) : e105568. PubMedID: 25162558
  • The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow.

    Kirabo A et al (2011)Neoplasia 13(11) : 1058-68. PubMedID: 22131881