MW: 434.3 Da CAS Registry #: 304896-28-4 Formula: C₂₃H₁₃Cl₂N₃O₂ Description:AGK2 is a selective, cell-permeable inhibitor of SIRT2. It has minimal effects SIRT1 and SIRT3 at 10-fold higher levels compared to SIRT2. Useful for studing SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis. Purity:

≥98% by HPLC

Biological Activity: AGK2 inhibits SIRT2 with an IC50 value of 3.5 µM. Solubility: Soluble in DMSO and DMF purged with an inert gas. Solubility is approximately 1mg/ml in DMSO and approximately 3 mg/ml in DMF. Format: A crystalline solid. Storage / Stability: Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. Reference(s): Outeiro, T.F., et al., Science. 2007;317:516-519. Scientific Category: HDAC Product Type: Inhibitor Data shown is lot-specific. Contact us for specific information on other lots.