Tocris/IT1t dihydrochloride/4596/50/50 mg-蚂蚁淘生物

Description: Potent CXCR4 antagonist Chemical Name: N,N\'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent CXCR4 antagonist (IC₅₀ = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC₅₀ = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).

Compound Libraries

IT1t dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	479.57
Formula	C₂₁H₃₄N₄S₂.2HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1092776-63-0
PubChem ID	25178351
InChI Key	HFXJOXOIINQOEB-UHFFFAOYSA-N
Smiles	CC1(C)CN(C(CS/C(NC4CCCCC4)=N/C3CCCCC3)=CS2)C2=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

water	47.96	100
DMSO	4.8	10
ethanol	23.98	50

Preparing Stock Solutions

The following data is based on the product molecular weight 479.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.09 mL	10.43 mL	20.85 mL
5 mM	0.42 mL	2.09 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution. Reconstitution Calculator

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Thoma et al (2008) Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J.Med.Chem. 51 7915 PMID: 19053768

Keywords: IT1t dihydrochloride, supplier, CXCR4, antagonists, HIV, envelope, protein, gp120, chemokines, receptors, type, 4, Antivirals, Chemokine, CXC, Receptors, Chemokine, CXC, Receptors, Tocris Bioscience