Tocris/Impentamine dihydrobromide/1858/10/10 mg-蚂蚁淘生物

Description: Selective H₃ antagonist Alternative Names: VUF 4702 Chemical Name: 4-(5-Aminopentyl)imidazole dihydrobromide Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent and highly selective histamine H₃ receptor antagonist (pA₂ = 8.4); displays > 30000-fold selectivity over H₁ and H₂ receptors. Can act as a partial agonist in SK-N-MC cells expressing human H₃ receptors. Produces antinociception, possibly via a non-H₁, -H₂ or -H₃ receptor-mediated mechanism, following central administration in vivo.

Technical Data

M. Wt	315.05
Formula	C₈H₁₅N₃.2HBr
Storage	Desiccate at RT
CAS Number	149629-70-9
PubChem ID	53439849
InChI Key	QSDXAAWBBPWGEL-UHFFFAOYSA-N
Smiles	Br.Br.NCCCCCC1=CN=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	31.51	100
water	31.51	100

Preparing Stock Solutions

The following data is based on the product molecular weight 315.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.17 mL	15.87 mL	31.74 mL
5 mM	0.63 mL	3.17 mL	6.35 mL
10 mM	0.32 mL	1.59 mL	3.17 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Hough et al (1999) Antinociceptive activity of impentamine, a histamine congener, after CNS administration. Life Sci. 64 PL79 PMID: 10072195

Vollinga et al (1995) Homologs of histamine as histamine H₃ receptor antagonists: a new potent and selective H₃ antagonist, 4(5)-(5-aminopentyl)-1H-imidazole. J.Med.Chem. 38 266 PMID: 7830269

Wieland et al (2001) Constitutive activity of histamine H₃ receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H₃ antagonists. J.Pharmacol.Exp.Ther. 299 908 PMID: 11714875

Keywords: Impentamine dihydrobromide, supplier, Selective, H3, antagonists, Receptors, Histamine, histaminergic, VUF4702, VUF, 4702, Histamine, H3, Receptors, Histamine, H3, Receptors, Tocris Bioscience