Tocris/EGLU/0971/50/50 mg-蚂蚁淘生物

Description: Highly selective group II mGlu antagonist Chemical Name: (2S)-α-Ethylglutamic acid Purity: ≥95% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord; presumed group II mGlu receptor antagonist. Also available as part of the Group II mGlu Receptor Tocriset™.

Technical Data

M. Wt	175.18
Formula	C₇H₁₃NO₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	170984-72-2
PubChem ID	5311079
InChI Key	QFYBYZLHPIALCZ-ZETCQYMHSA-N
Smiles	N[C@](CCC(O)=O)(CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility

Soluble to 100 mM in 1eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 175.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	5.71 mL	28.54 mL	57.08 mL
5 mM	1.14 mL	5.71 mL	11.42 mL
10 mM	0.57 mL	2.85 mL	5.71 mL
50 mM	0.11 mL	0.57 mL	1.14 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Jane et al (1996) Potent antagonists at L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate recpetors in neonatal rat spinal cord. Neuropharmacology 35 1029 PMID: 9121605

Thomas et al (1996) (S)-α-Ethylglutamic acid and (RS)-α-cyclopropyl-4-phosphonophenylglycine as antagonists of L-AP4- and (1S,3S)-ACPD-induced depression of monosynaptic excitation of neonatal rat motoneurones. Br.J.Pharmacol. 117 70P PMID:

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