Tocris/(1<em>S</em>,3<em>R</em>)-ACPD/0284/10/10 mg-蚂蚁淘生物

Description: Group I/group II mGlu agonist Chemical Name: (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Active isomer of (±)-trans-ACPD (Cat. No. 0187). Agonist at both group I and II mGlu receptors (EC₅₀ values are 5, 15, 42 and 60 μM at mGluR₂, mGluR₅, mGluR₁ and mGluR₆ respectively). NPEC-caged-(1S,3R)-ACPD also available (Cat. No. 3331). (±)-trans-ACPD (Cat. No. 0187) and cis-ACPD (Cat. No. 0186) also available.

Technical Data

M. Wt	173.17
Formula	C₇H₁₁NO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	111900-32-4
PubChem ID	104766
InChI Key	YFYNOWXBIBKGHB-FBCQKBJTSA-N
Smiles	N[C@]1([C@@](O)=O)C[C@]([H])([C@](O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

1eq. NaOH	17.32	100
water	5.2	30

Preparing Stock Solutions

The following data is based on the product molecular weight 173.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	5.77 mL	28.87 mL	57.75 mL
5 mM	1.15 mL	5.77 mL	11.55 mL
10 mM	0.58 mL	2.89 mL	5.77 mL
50 mM	0.12 mL	0.58 mL	1.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ²-isoxazoline-cyclopentance analogues of glutamic acid. Farmaco 57 889 PMID: 12484537

Knopfel et al (1995) Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 38 1417 PMID: 7738999

Mistry and Challis (1996) Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover. Br.J.Pharmacol. 117 1735 PMID: 8732284

Keywords: (1S,3R)-ACPD, supplier, Group, II, group, I, mGlur, agonists, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience