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Description

Angiotensinogen is also known as \"renin substrate,” and is a precursor for all angiotensin peptides. Angiotensinogen is an α-2-globulin produced in the liver in response to estrogen, thyroid, or corticosteroid signaling. Angiotensinogen is cleaved by renin, producing angiotensin I (AT I).

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References

Herichova I, Szantoova K. Renin-angiotensin system: upgrade of recent knowledge and perspectives. Endocr Regul. 2013 Jan;47(1):39-52. PMID: 23363256.

Kobori H, Urushihara M. Augmented intrarenal and urinary angiotensinogen in hypertension and chronic kidney disease. Pflugers Arch. 2013 Jan;465(1):3-12. PMID: 22918624.