中文名称：B细胞活化因子受体 靶点别称：B-Cell Activation Factor Receptor，BAFF-R，TNF Receptor Superfamily Member 13C，BLyS Receptor 3，B-Cell-Activating Factor Receptor，TNFRSF13C，B Cell-Activating Factor Receptor，Prolixin，BAFFR，BR3，Tumor Necrosis Factor Receptor Superfamily Member 13C，CVID4，Tumor 上市药物数量：0 临床药物数量：1 最高研发阶段：临床三期 BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. Morphosys Ag, 诺华制药 类风湿关节炎, 特发性肺纤维化, Sjtoegren综合征, 弥漫性大B-细胞淋巴瘤, 多发性硬化, 系统性红斑狼疮, 自身免疫性肝炎, 非霍奇金淋巴瘤, 慢性淋巴细胞白血病, 天疱疮 详情