AGScientific

国别：美国AG Scientific

AGScientific, the company was founded in San Diego, California, TM 1997, to accelerate scientific discovery. We strive to production of the most innovative and highest quality can be used in life science research, the biochemical. We are proud to customers are significant advances, molecular biology, neurobiology, cell biology, cancer research, drug discovery, the scientists of agricultural biotechnology and animal health.

AGScientific科学，公司成立于加利福尼亚州的圣迭戈市，在1997年的TM，加速科学发现的目的。我们力求生产的最具创新性和质量较高的可用于生命科学研究领域的生化试剂。我们很荣幸有客户正在显着进步，分子生物学，神经生物学，细胞生物学，癌症研究，药物发现，农业生物技术和动物健康的科学家。

Background

Hello, international scientists, my name is Chip Lindgren and I am the Founder & President of AG Scientific, Inc. Founded in 1997, we are focused on advancing drug development via innovative biochemicals for preclinical research, as well as, custom raw materials for diagnostic test development.

Philosophy

• We are proud to announce our 20th year in business.

• We were founded on being real people with a rapid response. We truly embrace the idiom, the early bird catches the worm. We want to be ever present on our website, on the phone, promptly preparing your price quote, delivering your product and exceeding your expectation. We encourage our client’s to put a name to the face.

• Currently, too many internet companies hide behind the unknown email address, reveal no detail on who you are working with, or even where the product is manufactured. We believe your trust is earned and not a given. We believe in lifelong partnerships!

• We have also seen a radical transformation in the Life Science industry. The consolidation of companies into mega-conglomerates has resulted in less personal service, automated phone extensions, slower response times, extensive overhead add-ons, laidback urgencies on deliveries and higher overall prices. This fact has left us invigorated to compete. We take great pleasure in the realization that working with AG Scientific, Inc. streamlines the order process, permitting you the same product with better service, upgraded delivery, and lower overall price.

Corporate Promise

• AGScientific, Inc., an ISO 9001: 2008 certified facility since 2005, will handle your projects with integrity and privacy. We will listen to your requirements and be extremely responsive to your needs. Comprehensive customer service and accountability at all phases of your project is our pledge. We value you as our customer and will work until your needs are met.

• AG Scientific’s team is straight forward, consisting of forthright people. We do not hide behind ‘the email curtain’. We will build a professional rapport, so you know who you are dealing with and who will be responsive to all your specific requirements. We take great pride returning to a true level of customer responsiveness that sets us apart in this marketplace. We value returning to a more person-to-person interaction; pick up the phone, video conference, visit the client. We want you to be 100% comfortable in our partnership.

• We will employ the highest quality standards to ensure the utmost accuracy. On time delivery is a hallmark of our organization. You will be consistently informed of the status of your project so that you can confidently & effectively communicate to your organization. Our desire is to make this the best overall experience and earn a life-long client. This is our solemn commitment to you.

History

• I am an educated microbiologist from the University of Massachusetts, Amherst

• We are established expert in fermentation derived secondary metabolites. Most products are antibiotics for gene selection, but products also include antimicrobial, anti-fungal, anti-cancer, antiviral, anti-parasitic and immunosuppressive reagents. Our breakthrough product was a partnership with Eli Lilly’s, Elanco division to purchase bulk Hygromycin B.

Antibiotics:

• Elanco used Hygromycin B in their pig feed but our application was the emergence of genetic engineering by performing plasmid cloning utilizing an antibiotic resistance marker. AG Scientific, Inc. developed a suite of Antibiotic selection agents including Blasticidin S, G-418, Puromycin, Gentamycin, Kanamycin, Ampicillin, Streptomycin, Carbenicillin…. We began successfully promoting this item at the time to all the leading Molecular Biology companies, Sigma Chemical, Stratagene, Invitrogen, Clontech, ICN, Amersham….

• Most recently we have partnered with pharmaceutical clients utilizing CRISPR technology. The same antibiotic selection is employed before CRISPR/Cas system is utilized. This has blown open the door to a number of inherited diseases previously only treated therapeutically.

Anti-Cancer:

• Our fermentation experience led to secondary metabolite opportunities in the field of cancer: products such as rapamycin, FK-506, Cyclosporin A. An early success story is the multi-kilogram scale development of the anti-tumor compound, Geldanamycin, with Infinity Pharmaceutical. Due to their better toxicity profile, the clinical candidates became semi-synthetic sister compounds 17-AAG & 17-DMAG. Sadly, AG Scientific being a young organization of 4 years old, preclinical focused and not ISO certified lead to the loss of the contract.

• We took this setback as motivation to become ISO 9001:2000 certified, incorporated internal packaging division and expand our corporate headquarters in San Diego, CA.

Enzymes:

• With the demonstration of our business to business (B2B) proficiency and internal packaging & private labeling capabilities, we secured partnerships to promote a series of enzymes extremely useful in the field of Molecular Biology. Specifically, microarray studies, real-time PCR, northern blots, or cDNA cloning applications.

• Proteinase K enzyme is used for the isolation of clean and native genomic DNA and RNA in order to guarantee PCR-based detection became a breakthrough product for us. A sister compound, RNase A, removes RNA became a potent 1-2 punch in the B2B market, as well as, business to consumer(B2C) marketplace. We then added a series of related items such as buffers, biological detergents, and inhibitors. Typical examples are DTT, Guanidine HCl, Tris, KCl, AEBSF, PMSF, MgCl2, Triton X-100, Tween 20, and NP-40…

• Another enzyme partnership continued the expansion and elatedly deepened our product offering & applications within the antibiotic, diagnostic & medical device markets (read above & below).

Diagnostics:

• In late 1999, we developed & launched a novel line of Protease, Phosphatase inhibitors, as well as, custom Protease inhibitor cocktails (PICS). These were customized to their protein or Biomarker of interest. Rapid enzyme inactivation was essential to preservation & stabilization of the protein biomarker.

• These reagents have vast applications in the field of Proteomics, as well as, diagnostic test development. The market leader, Roche’s PIC tablet format took a long time to dissolve and inactivate enzymes.

• We incorporated larger surface area, faster inactivation via lyophilized PICS. In the years’ since its introduction, we have secured numerous Diagnostic clients in the Human & cCmpanion animal diagnostic marketplace. We are proud to state Diagnostics has grown to be our 2nd largest product line.

Medical Device:

• The fermentation/metabolite experience has led to another beneficial product line. This is the supply of ionophores components to the in vitro diagnostic (IVD) Medical Device industry. Naturally fermented ionophores such as Valinomycin, Ionomycin, A23187, Nigericin, Nonactin, Enniatins, Alamethicin,…are used as Ion Select Electrodes (ISE).

• Synthetically, produced ionophores such as Lithium Ionophore VIII, CA-1001, Monensin Methyl Ester… can be used as an ISE, as well as, ionophore based Optical Sensor (IBOS). These compounds hold great promise in the rapidly growing market of wearable biosensors and have proved to be a growing marketplace for AG Scientific.

Future:

• AG Scientific’s future is bright. Our main product lines: Antibiotics, Proteomics, Diagnostic and Medical Device have shown year to year growth for the last three years. Short term, we are poised to attain deeper penetration in Proteomics marketplace with our superior services, response time, diverse product offering will lead to substantial growth.

• According to PR Newswire forecast, January 10th 2017 Proteomics Market by Instrument, Reagent & Service, Application at a compound annual growth rate (CAGR) of 11.7% during the forecast period of 2016 to 2021, http://www.prnewswire.com/news-releases/proteomics-market-by-instrument-reagent--service-application---forecast-to-2021-300388802.html

• ALBANY, New York, January 25, 2017, /PRNewswire/ -- According to the research report, the global molecular diagnostic market is estimated to reach a valuation of US$18.9 bn by the end of 2025 as compared to US$7.1 bn in 2016. Between the forecast years of 2016 and 2025, the global market is estimated to expand at a steady CAGR of 11.6%. http://www.prnewswire.com/news-releases/global-molecular-diagnostics-market-to-reach-us189-billion-by-2025-continuous-evolution-of-molecular-biology-augurs-well-for-growth-states-tmr-611745785.html

• Longer term, we deem deeper penetration in the diagnostic & medical device is required. Additional certification in ISO 13485, Medical Devices is warranted. This market requires a more intense qualification process but in return, we receive better gross margins, improved supply security, as well as, greater pricing independence.

Sincerely,

Chip Lindgren

CEO/Founder

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