Tocris/VUF 11207 fumarate/4780/50/50 mg-蚂蚁淘生物

Description: Potent ACKR3 (CXCR7) agonist Chemical Name: N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent ACKR3 (CXCR7) chemokine receptor agonist (EC₅₀ = 1.6 nM). Induces recruitment of β-arrestin to CXCR7 in HEK293-CXCR7 cells.

Compound Libraries

VUF 11207 fumarate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	586.65
Formula	C₂₇H₃₅FN₂O₄.C₄H₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	90488970
InChI Key	MTPOECCHJLVVGO-FDULSSLPSA-N
Smiles	CC(CN(CCC2N(C)CCC2)C(C3=CC(OC)=C(OC)C(OC)=C3)=O)=C/C1=C(F)C=CC=C1.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	58.66	100
water	58.66	100

Preparing Stock Solutions

The following data is based on the product molecular weight 586.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	1.7 mL	8.52 mL	17.05 mL
5 mM	0.34 mL	1.7 mL	3.41 mL
10 mM	0.17 mL	0.85 mL	1.7 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Wijtmans et al (2012) Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur.J.Med.Chem. 51 184 PMID: 22424612

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