Tocris/CGP 54626 hydrochloride/1088/10/10 mg-蚂蚁淘生物

Description: Potent, selective GABA_B antagonist Chemical Name: [S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid Purity: ≥96% Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

A potent, selective GABA_B receptor antagonist (IC₅₀ = 4 nM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Compound Libraries

CGP 54626 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	444.76
Formula	C₁₈H₂₈Cl₂NO₃P.HCl
Storage	Store at RT
Purity	≥96%
CAS Number	149184-21-4
PubChem ID	197583
InChI Key	ZQCFHOVIXCJPLE-LINSIKMZSA-N
Smiles	OP(CC1CCCCC1)(C[C@@H](O)CN[C@@H](C)C2=CC(Cl)=C(Cl)C=C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	22.24	50
ethanol	4.45	10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 444.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.25 mL	11.24 mL	22.48 mL
5 mM	0.45 mL	2.25 mL	4.5 mL
10 mM	0.22 mL	1.12 mL	2.25 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Brugger et al (1993) The action of new potent GABA_B receptor antagonists in the hemisected spinal cord preparation of the rat. Eur.J.Pharmacol. 235 153 PMID: 8390938

Kaupmann et al (1998) GABA_B-receptor subtypes assemble into functional heteromeric complexes. Nature 396 683 PMID: 9872317

Froestl et al (1996) Potent, orally active GABA_B receptor antagonists. Pharmacol.Rev.Comm. 8 127 PMID:

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