关于 Tocris | Tocris 生物科学,Tocris/SB 265610/2724/1/1 mg-蚂蚁淘生物

Description: Potent CXCR2 antagonist Chemical Name: N-(2-Bromophenyl)-N\'-(7-cyano-1H-benzotriazol-4-yl)urea Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca²⁺ mobilization (IC₅₀ values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt	357.16
Formula	C₁₄H₉BrN₆O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	211096-49-0
PubChem ID	9841667
InChI Key	SEDUMQWZEOMXSO-UHFFFAOYSA-N
Smiles	O=C(NC3=C(Br)C=CC=C3)NC1=CC=C(C#N)C2=C1NN=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	35.72	100
ethanol	3.57	10

Preparing Stock Solutions

The following data is based on the product molecular weight 357.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.8 mL	14 mL	28 mL
5 mM	0.56 mL	2.8 mL	5.6 mL
10 mM	0.28 mL	1.4 mL	2.8 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Auten et al (2001) Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J.Pharmacol.Exp.Ther. 299 90 PMID: 11561067

Milatovic et al (2003) Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Wound Repair Regen. 11 213 PMID: 12753603

Keywords: SB 265610, supplier, Potent, CXCR2, antagonists, Chemokine, Receptors, SB265610, GlaxoSmithKline, GSK, Chemokine, CXC, Receptors, Chemokine, CXC, Receptors, Tocris Bioscience