用户帐号 | Tocris 生物科学,Tocris/PSB 603/3198/10/10 mg-蚂蚁淘生物

Description: Highly selective A_2B antagonist Chemical Name: 8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Adenosine A_2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (K_i values are 0.553, > 10000, > 10000 and > 10000 nM for A_2B, A₁, A_2A and A₃ receptors respectively).

Compound Libraries

PSB 603 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	529.01
Formula	C₂₄H₂₅ClN₆O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1092351-10-4
PubChem ID	44185871
InChI Key	OVHCTHHFOHMNFV-UHFFFAOYSA-N
Smiles	O=C(NC2=C1NC(C3=CC=C(S(N4CCN(C5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO

26.45

Preparing Stock Solutions

The following data is based on the product molecular weight 529.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	1.89 mL	9.45 mL	18.9 mL
5 mM	0.38 mL	1.89 mL	3.78 mL
10 mM	0.19 mL	0.95 mL	1.89 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Borrmann et al (2009) 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 52 3994 PMID: 19569717

Keywords: PSB 603, supplier, selective, A2B, antagonists, Receptors, adenosines, PSB603, Adenosine, A2B, Receptors, Adenosine, A2B, Receptors, Tocris Bioscience