Description: Potent and selective FFA4 (GPR120) agonist Chemical Name: 4-[(4-Fluoro-4\'-methyl[1,1\'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent FFA4 (GPR120) agonist (pEC₅₀ values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC₅₀ = 4.19 for FFA1; displays no activity at FFA2 or FFA3). Cell permeable.

Licensing Information

Sold under license from the University of Southern Denmark.

Compound Libraries

TUG 891 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	364.41
Formula	C23H21FO3
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1374516-07-0
PubChem ID	57522038
InChI Key	LPGBXHWIQNZEJB-UHFFFAOYSA-N
Smiles	FC1=CC(COC2=CC=C(CCC(O)=O)C=C2)=C(C3=CC=C(C)C=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	36.44	100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Shimpukade et al (2012) Discovery of a potent and selective GPR120 agonist. J.Med.Chem. 55 4511 PMID: 22519963

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