代谢型谷氨酸受体科学评论 | Tocris 生物科学,Tocris/ZQ 16/6001/10/10 mg-蚂蚁淘生物

Description: Selective GPR84 agonist Chemical Name: 2-(Hexylthio)-6-hydroxy-4(3H)-pyrimidinone Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Selective medium-chain free fatty acid receptor GPR84 agonist (EC₅₀ = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 uM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro.

Technical Data

M. Wt	228.31
Formula	C₁₀H₁₆N₂O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	376616-73-8
PubChem ID	1912564
InChI Key	UYXOAKRMLQKLQX-UHFFFAOYSA-N
Smiles	CCCCCCSC1=NC(O)=CC(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	11.42	50
ethanol	22.83	100

Preparing Stock Solutions

The following data is based on the product molecular weight 228.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	4.38 mL	21.9 mL	43.8 mL
5 mM	0.88 mL	4.38 mL	8.76 mL
10 mM	0.44 mL	2.19 mL	4.38 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Liu et al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579 PMID: 27326330

Zhang et al (2016) Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 357 337 PMID: 26962172

Keywords: ZQ 16, supplier, ZQ16, selective, medium, chain, free, fatty, acid, receptor, GPR84, agonists, agonism, Free, Fatty, Acid, Receptors, Free, Fatty, Acid, Receptors, Tocris Bioscience