索取文献 | Tocris 生物科学,Tocris/DCG IV/0975/10/10 mg-蚂蚁淘生物

Description: Very potent, selective group II mGlu agonist. Also NMDA agonist Chemical Name: (2S,2\'R,3\'R)-2-(2\',3\'-Dicarboxycyclopropyl)glycine Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Presynaptic depressant; highly potent agonist for group II mGlu receptors. Also available as part of the Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™.

Licensing Information

Sold with the permission of Suntory Ltd.

Technical Data

M. Wt	203.15
Formula	C₇H₉NO₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	147782-19-2
PubChem ID	16758827
InChI Key	MATPZHBYOVDBLI-FKNRSBSYSA-N
Smiles	N[C@]([H])(C(O)=O)[C@]1(C([H])(C(O)=O)C([H])1C(O)=O)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

phosphate buffered saline	20.32	100
water	20.32	100

Preparing Stock Solutions

The following data is based on the product molecular weight 203.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	4.92 mL	24.61 mL	49.22 mL
5 mM	0.98 mL	4.92 mL	9.84 mL
10 mM	0.49 mL	2.46 mL	4.92 mL
50 mM	0.1 mL	0.49 mL	0.98 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Brabet et al (1998) Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 37 1043 PMID: 9833633

Cartmell et al (1998) Characterization of [³H]-(2S,2\'R,3\'R)-2-(2\',3\'-dicarboxycyclopropyl)glycine ([³H]-DCG IV) binding to metabotropic mGlu₂ receptor-transfected cell membranes. Br.J.Pharmacol. 123 497 PMID: 9504391

Ishida et al (1993) A novel metabotropic receptor agonist: marked depression of monosynaptic excitation in the isolated rat spinal cord. Br.J.Pharmacol. 109 1169 PMID: 8401927

Ohfune et al (1993) Synthesis of L-2-(2,3-dicarboxycyclopropyl)-glycines. Novel conformationally restricted glutamate analogues. Bioorg.Med.Chem.Lett. 3 15 PMID:

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