索取文献 | Tocris 生物科学,Tocris/ACPT-II/1112/50/50 mg-蚂蚁淘生物

Description: Competitive mGlu receptor antagonist Chemical Name: (1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Competitive metabotropic receptor antagonist (K_B values are 115, 88 and 77 μM at mGlu_1a, mGlu₂ and mGlu_4a respectively).

Licensing Information

Sold with the permission of the CNRS

Technical Data

M. Wt	217.18
Formula	C₈H₁₁NO₆
Storage	Desiccate at -20°C
CAS Number	195209-04-2
PubChem ID	5280961
InChI Key	TZBJGXHYKVUXJN-UHFFFAOYSA-N
Smiles	N[C@]1([C@@](O)=O)C[C@H]([C@](O)=O)[C@H]([C@@](O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility

Soluble to 5 mM in DMSO and to 100 mM in 1.4 eq. NaOH

Preparing Stock Solutions

The following data is based on the product molecular weight 217.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	4.6 mL	23.02 mL	46.04 mL
5 mM	0.92 mL	4.6 mL	9.21 mL
10 mM	0.46 mL	2.3 mL	4.6 mL
50 mM	0.09 mL	0.46 mL	0.92 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119 PMID: 9301676

Bessis et al (2002) Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists. Proc.Natl.Acad.Sci.U.S.A. 99 11097 PMID: 12151600

Keywords: ACPT-II, supplier, Competitive, receptor, antagonists, Non-Selective, Receptors, Metabotropic, Glutamate, Non-selective, mGlu, Non-selective, mGlu, Tocris Bioscience