Biological Activity
Potent and highly selective histamine H3 receptor agonist (pEC50 = 9.74) that displays 300-fold selectivity over the H4 receptor (pKi values are 9.07 and 6.61 respectively). Does not bind to H1 or H2 receptors at concentrations up to 10 μM. .
Technical Data
| M. Wt | 321.01 |
| Formula | C9H9N3.2HBr |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 699020-93-4 |
| PubChem ID | 16759172 |
| InChI Key | CYNKWHIKNDIVDR-UHFFFAOYSA-N |
| Smiles | Br.Br.C(C1=CN=CN1)C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| water | 32.1 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 321.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 3.12 mL | 15.58 mL | 31.15 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.23 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383
Keywords: Immethridine dihydrobromide, supplier, Potent, H3, agonists, selective, over, H4, Receptors, Histamine, histaminergic, Histamine, H3, Receptors, Histamine, H3, Receptors, Tocris Bioscience
