索取文献 | Tocris 生物科学,Tocris/4-CMTB/4642/10/10 mg-蚂蚁淘生物

Description: FFA2 agonist; also exhibits positive allosteric modulatory activity Chemical Name: 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Free fatty acid receptor FFA2 agonist (pEC₅₀ = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

Compound Libraries

4-CMTB is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	294.8
Formula	C₁₄H₁₅ClN₂OS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	300851-67-6
PubChem ID	4307629
InChI Key	AZYDQCGCBQYFSE-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C(C(C)C)C(NC2=NC=CS2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	29.48	100
ethanol	5.9	20

Preparing Stock Solutions

The following data is based on the product molecular weight 294.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.39 mL	16.96 mL	33.92 mL
5 mM	0.68 mL	3.39 mL	6.78 mL
10 mM	0.34 mL	1.7 mL	3.39 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Smith et al (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol.Pharmacol. 80 163 PMID: 21498659

Milligan et al (2009) Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br.J.Pharmacol. 158 146 PMID: 19719777

Keywords: 4-CMTB, supplier, free, fatty, acid, receptors, FFA, FFA2, agonists, positive, allosteric, modulators, pams, Free, Fatty, Acid, Receptors, Free, Fatty, Acid, Receptors, Tocris Bioscience