Biological Activity
Hec1 inhibitor. Binds Hec1, inhibiting its association with Nek2 and kinetochores. Causes arrest of mitosis and inhibits proliferation in breast cancer cell lines (GI50= 10 - 20 μM).
Technical Data
| M. Wt | 344.86 |
| Formula | C18H16N2OS.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 313553-47-8 |
| PubChem ID | 71307591 |
| InChI Key | DYJVVODHGPIUPM-UHFFFAOYSA-N |
| Smiles | CC(C=C(C)C=C2)=C2C1=CSC(NC(C3=CC=CC=C3)=O)=N1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 30.84 | 100 |
| ethanol | 3.08 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 344.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 2.9 mL | 14.5 mL | 29 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.8 mL |
| 10 mM | 0.29 mL | 1.45 mL | 2.9 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Wu et al (2008) Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 68 8393 PMID: 18922912
Keywords: INH1, supplier, Hec1, inhibitors, inhibits, mitosis, arrests, Mitosis, Mitosis, Tocris Bioscience
