索取文献 | Tocris 生物科学,Tocris/OAC-2/6066/50/50 mg-蚂蚁淘生物

Description: Oct4 activator; enhances iPSC reprogramming efficiency Chemical Name: N-(1H-Indol-5-yl)benzamide Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Oct 4 activator; enhances iPSC reprogramming four-fold and accelerates the appearance of iPSC colonies in combination with 4F (Oct4, Sox2, c-Myc and Klf4). Also induces cardiomyocyte-like cells from human fibroblasts, as part of the 9C cocktail (CHIR99021, A83-01, BIX01294, AS83541, SC1, Y27632, SU 16f, JNJ10198409 and OAC-2)

Technical Data

M. Wt	236.27
Formula	C₁₅H₁₂N₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	6019-39-2
PubChem ID	2814138
InChI Key	JCAFGYWSIWYMOX-UHFFFAOYSA-N
Smiles	O=C(C1=CC=CC=C1)NC2=CC=C3C(C=CN3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	23.63	100
ethanol	23.63	100

Preparing Stock Solutions

The following data is based on the product molecular weight 236.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	4.23 mL	21.16 mL	42.32 mL
5 mM	0.85 mL	4.23 mL	8.46 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Li et al (2012) Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc.Natl.Acad.Sci.USA. 109 20853 PMID: 23213213

Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 1216 PMID: 27127239

Keywords: OAC-2, supplier, iPSCs, reprogramming, factors, Oct4, activators, Sox2, Nanog, inducers, enhances, accelerates, inducible, pluripotent, stem, cells, Reprogramming, Other, Transcription, Factors, Reprogramming, Tocris Bioscience