Biological Activity
Potent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).
Technical Data
| M. Wt | 290.36 |
| Formula | C18H18N4 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 55778-02-4 |
| PubChem ID | 11565518 |
| InChI Key | KBVFRXIGQQRMEF-UHFFFAOYSA-N |
| Smiles | C1(CNC3=NC=CC=C3)=CC=C(CNC2=NC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 7.26 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 290.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 3.44 mL | 17.22 mL | 34.44 mL |
| 5 mM | 0.69 mL | 3.44 mL | 6.89 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.44 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Zhan et al (2007) Discovery of small molecule CXCR4 antagonists. J.Med.Chem. 50 5655 PMID: 17958344
Reyes et al (2002) Pyridinium N-(2\'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines. Chem.Inform. 34 PMID:
Keywords: WZ 811, supplier, WZ811, chemokine, receptors, receptor, type, 4, antagonists, CXCR4, Chemokine, CXC, Receptors, Chemokine, CXC, Receptors, Tocris Bioscience
