索取文献 | Tocris 生物科学,Tocris/MNI 137/4388/50/50 mg-蚂蚁淘生物

Description: Selective negative allosteric modulator of group II mGlu receptors Chemical Name: 4-(8-Bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile Purity: ≥98% (HPLC)Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Selective negative allosteric modulator of group II mGlu receptors (IC₅₀ values are 8.3 and 12.6 nM for human and rat mGlu₂ inhibition of glutamate-induced calcium mobilization). Displays no activity at mGlu₁, mGlu₄, mGlu₅ or mGlu₈ receptors in a calcium mobilization assay.

Technical Data

M. Wt	341.16
Formula	C₁₅H₉BrN₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	946619-21-2
PubChem ID	25210562
InChI Key	KMKZCMKOSAKVGY-UHFFFAOYSA-N
Smiles	O=C1CC(C3=CC=NC(C#N)=C3)=NC2=C(C=C(Br)C=C2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO

17.06

Preparing Stock Solutions

The following data is based on the product molecular weight 341.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	2.93 mL	14.66 mL	29.31 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.47 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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Product Datasheets

Certificate of Analysis / Product DatasheetSafety DatasheetSelect another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Hemstapat et al (2007) A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 322 254 PMID: 17416742

Keywords: MNI 137, supplier, MNI137, glutamate, mGluRs, receptors, group, II, negative, allosteric, modulators, NAMs, selective, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience