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Tocris/VU 0409106/5322/10/10 mg
Description: Potent and selective negative allosteric modulator at mGlu5 Chemical Name: 3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Potent and selective mGlu5 negative allosteric modulator (IC50 = 49 nM at human mGlu5). Selective for mGlu5 over a panel of GPCRs and ion channels. Exhibits no significant nonspecific binding in rat brain homogenates in vitro. Inhibits marble burying behavior in mice. Brain penetrant.

Technical Data

M. Wt 330.34
Formula C15H11FN4O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1276617-62-9
PubChem ID 50990953
InChI Key AXVLPJHYYFHCHK-UHFFFAOYSA-N
Smiles FC1=CC(OC2=CN=CN=C2)=CC(C(NC3=NC(C)=CS3)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility
DMSO 33.03 100

Preparing Stock Solutions

The following data is based on the product molecular weight 330.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.14 mL 30.27 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL
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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Felts et al (2013) Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorg.Med.Chem.Lett. 23 5779 PMID: 24074843


Keywords: VU 0409106, supplier, VU0409106, metabotropic, glutamate, receptors, negative, allosteric, modulators, NAMs, mGluR5, class, I, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience