说明： Binds cereblon, inhibiting ubiquitin ligase activity; alsoTNF-a synthesis inhibitor化学名： N-(2,6-dioxo-3-piperidinyl)phthalimide纯度： 99% (HPLC) 生物活性

Selective inhibitor of tumor necrosis factor (TNF- ) synthesis. Anti-inflammatory; promotes T-cell activation. Predicted to reduce cytokine release in SARS-CoV-2 infection. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogenic and sedative-hypnotic. Promotes degradation of transcription factor SALL4.

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et al (1997)Thal. reduces MPTP-induced decrease in striatal DA levels in mice.Neurosci.Lett. 234 123 PMID:9364513

Kanbayashi et al (1996)Thal., a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy.Neuroreport 7 1881 PMID:8905685

Makonkawkeyoon et al (1993)Thal. inhibits the replication of human-immunodeficiency-virus type 1.Proc.Natl.Acad.Sci.U.S.A. 90 5974 PMID:8327469

Zhang et al (2008)Thal. influences growth and vasculogenic mimicry channel formation in melanoma.J.Exp.Clin.Cancer Res. 27 60 PMID:18983651

Sampaio et al (1991)Thal. selectively inhibits tumor necrosis factor production by stimulated human monocytes.J.Exp.Med. 173 699 PMID:1997652

Merck Index 12 9390

et al (2010)Identification of a primary target of Thal. teratogenicity.Science 327 1345 PMID:20223979

Donovan et al (2018)Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome.Elife 7 e38430 PMID:30067223

et al (2020) Network bioinformatics analysis provides insight into drug repurposing for COVID-2019 Preprint - Paper not yet peer reviewed..

If you know of a relevant reference for Thalidomide, please let us know.

关键词: Thalidomide, Thalidomide supplier, TNF- , TNF-alpha, synthesis, inhibitors, inhibits, Interleukins, Tumor, Necrosis, Factor- , Factor-alpha, Cytokines, Signaling, Signalling, teratogen, anti-inflammatory, angiogenesis, cereblon, ubiquitin, E3, ligase, SALL4, SARS-Cov-2, COVID-19, coronaviruses, severe, a, Antiangiogenics, Ubiquitin, Ligases, Other, Transcription, Factors, 0652, Tocris Bioscience

WARNING: This product can expose you to chemicals including Thalidomide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov 12 篇 Thalidomide 的引用文献 引用文献是使用了 Tocris 产品的出版物。 Thalidomide 的部分引用包括： Helmy et al (2015)Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs. PLoS One 10 e0142303 PMID:26536032Sung et al (2009)Curcumin circumvents chemoresistance in vitro and potentiates the effect of Thal. and borte. against human multiple myeloma in nude mice model. Mol Cancer Ther 8 959 PMID:19372569Eter and Spitznas (2002)DMSO mimics inhibitory effect of Thal. on choriocapillary endothelial cell proliferation in culture. Oncol Lett 86 1303 PMID:12386094Prete et al (2016)Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. J Biol Chem 291 17209 PMID:27325702Girgis et al (2010)Effect of Thal. and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line. MBio 1 663 PMID:22966360et al (2007)Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood 110 2286 PMID:17609425Pathak et al (2007)Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 5 943 PMID:17855663Kannappan et al (2010)γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents. J Biol Chem 285 33520 PMID:20720018et al (2010)Intraperitoneal injection of Thal. attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model. Mol Pain 6 64 PMID:20923560Pandey et al (2010)Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. Int J Cancer 127 282 PMID:19937797Sandur et al (2010)5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. Mol Cancer Res 8 107 PMID:20068065Rocha et al (2006)Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw. Br J Pharmacol 148 688 PMID:16702985

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