Prototypic vanilloid receptor agonist (pEC50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets. Also available as part of the Vanilloid TRPV1 Receptor Tocriset .
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
以下数据基于产品分子量 305.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. Molarity Calculator Calculate the mass, volume, or concentration required for a solution.*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
关键词: (E)-Capsaicin, (E)-Capsaicin supplier, Prototypic, vanilloid, receptor, agonists, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, 0462, Tocris Bioscience
et al (2015)Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Front Cell Neurosci 21 4852 PMID:25944998Zakharov et al (2015)Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers. J Transl Med 9 287 PMID:26283923Wang et al (2015)Mother root of Aconitum carmichaelii Debeaux exerts antinociceptive effect in Complet Freund s Adjuvant-induced mice: roles of dynorpin/κ-opioid system and transient receptor potential vanilloid type-1 ion channel. PLoS One 13 284 PMID:26320055Chen et al (2015)Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner. Nature 10 e0145556 PMID:26700862Stanley et al (2015)Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation. Neuropsychopharmacology 107 568 PMID:26092099Bhaskaran and Smith (2010)Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy. World J Gastroenterol 223 529 PMID:20144892Ahern et al (2005)Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J Neurosci 25 5109 PMID:15917451Bautista et al (2005)Pungent products from garlic activate the sensory ion channel TRPA1. Br J Pharmacol 102 12248 PMID:16103371Bang et al (2004)Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-α-mediated apoptotic liver damage. J Neurosci 308 1174 PMID:14617692Chen et al (2014)Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. Mol Pain 20 1298 PMID:24574803Cobellis et al (2010)A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up. Biol Reprod 82 451 PMID:19812302Diniz et al (2019)Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors. PeerJ 7 e6493 PMID:30809460Hartley et al (2013)Development and experimental application of an HPLC procedure for the determination of capsaicin and dihydrocapsaicin in serum samples from human subjects. Indian J Clin Biochem 28 329 PMID:24426233Nesuashvili et al (2013)Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol 83 1007 PMID:23444014Nash et al (2012)7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersen J Pharmacol Exp Ther 342 389 PMID:22566669Melis et al (2004)Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area DA neurons through activation of CB1 receptors. J Neurosci 24 53 PMID:14715937Yissachar et al (2017)An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell 168 1135 PMID:28262351Rossi et al (2014)Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. Mol Neurodegener 9 56 PMID:25495224Wang et al (2014)Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol 307 G719 PMID:25147231Nguyen et al (2014)Transient receptor potential vanilloid type 1 channel may modulate opioid reward. Neuropsychopharmacology 39 2414 PMID:24732880Benninger et al (2008)Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice. Br J Pharmacol 52 89 PMID:17651868Smart et al (2002)Entourage effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. Headache 136 452 PMID:12023948Izzo et al (2001)Effect of vanilloid drugs on gastrointestinal transit in mice. Br J Pharmacol 132 1411 PMID:11264233Craib et al (2001)A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. Neurochem Int 134 42581 PMID:11522594et al (2015)Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin. Mol Pain 11 22 PMID:25896608Chiu et al (2013)Bacteria activate sensory neurons that modulate pain and inflammation. World J Gastroenterol 501 52 PMID:23965627Shabir et al (2013)Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Diabetes 305 F396 PMID:23720349et al (2012)Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse. Acta Neurochir Suppl 61 1381 PMID:22492526Gibson et al (2008)TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57 746 PMID:18341994Balleza-Tapia et al (2018)TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro. Elife 7 PMID:30417826Chen et al (2016)Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk. Sci Rep 6 33307 PMID:27653550Khatibi et al (2011)Capsaicin pre-treatment provides neurovascular protection against neonatal hypoxic-ischemic brain injury in rats. Mol Pain 111 225 PMID:21725760Martínez-García et al (2011)Increase of capsaicin-induced trigeminal Fos-like immunoreactivity by 5-HT(7) receptors. Cardiovasc Res 51 1511 PMID:22082421Zsombok et al (2011)Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. Exp Neurol 31 14024 PMID:21957263Westlund et al (2010)Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior. Proc Natl Acad Sci U S A 6 46 PMID:20691059Pitcher et al (2007)Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia. J Pharmacol Exp Ther 3 17 PMID:17603899Fairless et al (2013)Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS One 8 e58260 PMID:23516458Buznikov et al (2010)A putative pre-nervous endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID:19907129$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris 提供以下领域的科研文献，以展现我们的产品。您不妨现在就索取*或下载所需的文献！
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.Bio-TechneWHERE SCIENCE INTERSECTS INNOVATIONTM
