Tocris/Dimaprit dihydrochloride/0506/100/100 mg-蚂蚁淘生物

Description: Standard H₂ selective agonist Chemical Name: S-(3-Dimethylaminopropyl)isothiourea dihydrochloride Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Selective H₂ agonist with central effects upon systemic administration. Also inhibits nNOS (IC₅₀ = 49 μM).

Technical Data

M. Wt	234.19
Formula	C₆H₁₅N₃S.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	23256-33-9
PubChem ID	90045
InChI Key	DFWCPLGXFMSUCW-UHFFFAOYSA-N
Smiles	CN(C)CCCSC(N)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

phosphate buffered saline	23.42	100mM with gentle warming
water	23.42	100

Preparing Stock Solutions

The following data is based on the product molecular weight 234.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	4.27 mL	21.35 mL	42.7 mL
5 mM	0.85 mL	4.27 mL	8.54 mL
10 mM	0.43 mL	2.14 mL	4.27 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products\' biological activity.

Durant et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H₂-receptor agonist. Part 2. Structure activity considerations. Agents Actions 7 39 PMID: 860674

Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276

Paquay et al (1999) Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 127 331 PMID: 10385230

Parsons et al (1977) Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H₂-receptor agonist. Part 1. Pharmacology. Agents Actions 7 31 PMID: 871093

Keywords: Dimaprit dihydrochloride, supplier, H2, selective, agonists, Receptors, Histamine, histaminergic, Histamine, H2, Receptors, Histamine, H2, Receptors, Tocris Bioscience