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自噬：机制和功能Patricia Boya，CSICPatrice Codogno，巴黎笛卡尔大学
细胞自噬是细胞用于降解和回收的细胞过程。此海报由 Patricia Boya 和 Patrice Codogno 撰写，总结了自噬分子机械、生理学和病理学自噬学。列出了 Tocris 提供的化合物。
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关闭开始聊天14.3.3 蛋白质肽抑制剂No.Product Name / Activity2144R18Inhibitor of 14.3.3 proteins特色新产品7645 | FHT 2344强效 SMARCA2/4 抑制剂7892 |用于标记突变体 FKBP12F36V 蛋白的 dTAG-荧光素荧光探针7368 | Cell Counting Kit-8细胞活力及增殖检测试液7842 | NAMPT PROTAC® A7强效选择性烟酰胺磷酸核糖转移酶降解剂7898 | ZZL 7 SERT 和 nNOS 之间相互作用的抑制剂我们如何帮助您？
关闭开始聊天其他还原酶其他还原酶抑制剂No.Product Name / Activity3812Cl-4AS-1 I 型和 II 型 5α-还原酶抑制剂3293Finasteride II 型 5α-还原酶抑制剂5842MK 386强效选择性人 1 型 5α-还原酶抑制剂7821ML 162 NewInhibits glutathione peroxidase (GPX4);诱导铁死亡61181S，3R-RSL3抑制谷胱甘肽过氧化物酶（GPX4）；诱导 ferroptosis6597SPRi 3 有效的墨蝶呤还原酶 (SPR) 抑制剂；减弱 CD4+ T 细胞的增殖3813TFM-4AS-1 I 型和 II 型 5α-还原酶抑制剂其他还原酶激活剂猫。 No.Product Name / Activity7162iFSP1Ferroptosis suppressor protein 1 (FSP1) 抑制剂； ferroptosis 诱导剂ControlsCat. No.Product Name / Activity66871R,3R-RSL3Negative control for 1S,3R-RSL3（货号 6118）特色新产品7645 | FHT 2344强效 SMARCA2/4 抑制剂7892 |用于标记突变体 FKBP12F36V 蛋白的 dTAG-荧光素荧光探针7368 | Cell Counting Kit-8细胞活力及增殖检测试液7842 | NAMPT PROTAC® A7P高效选择性烟酰胺磷酸核糖转移酶 Degrader7898 | ZZL 7 SERT 和 nNOS 之间相互作用的抑制剂我们如何帮助您？
关闭开始聊天其他异构酶其他异构酶抑制剂No.Product Name / Activity1101Cyclosporin ACyclophilin（肽基脯氨酰异构酶）抑制剂；还抑制钙调素 5389Ro 48-8071 富马酸盐 2,3-氧化角鲨烯环化酶 (OSC) 抑制剂特色新产品7645 | FHT 2344强效 SMARCA2/4 抑制剂7892 |用于标记突变体 FKBP12F36V 蛋白的 dTAG-荧光素荧光探针7368 | Cell Counting Kit-8细胞活力及增殖检测试液7842 | NAMPT PROTAC® A7强效选择性烟酰胺磷酸核糖转移酶降解剂7898 | ZZL 7 SERT 和 nNOS 之间相互作用的抑制剂我们如何帮助您？
关闭开始聊天所有靶标：YPharmacological 和细胞靶标按字母顺序列出0-9ABCDEFGHIJKLMNOPQRSTUVWXYZ
YAPFeatured New Products7645 | FHT 2344强效 SMARCA2/4 抑制剂7892 |用于标记突变体 FKBP12F36V 蛋白的 dTAG-荧光素荧光探针7368 | Cell Counting Kit-8细胞活力及增殖检测试液7842 | NAMPT PROTAC® A7强效选择性烟酰胺磷酸核糖转移酶降解剂7898 | ZZL 7 SERT 和 nNOS 之间相互作用的抑制剂我们如何帮助您？
关闭开始聊天所有靶标：X药理学和细胞靶标按字母顺序列出0-9ABCDEFGHIJKLMNOPQRSTUVWXYZ
X-Linked Inhibitor of ApoptosisXanthine oxidaseXIAPFeatured New Products7645 | FHT 2344强效 SMARCA2/4 抑制剂7892 |用于标记突变体 FKBP12F36V 蛋白的 dTAG-荧光素荧光探针7368 | Cell Counting Kit-8细胞活力及增殖检测试液7842 | NAMPT PROTAC® A7强效选择性烟酰胺磷酸核糖转移酶降解剂7898 | ZZL 7 SERT 和 nNOS 之间相互作用的抑制剂我们如何帮助您？
关闭开始聊天所有靶标：按字母顺序列出的 WPharmacological 和细胞靶标0-9ABCDEFGHIJKLMNOPQRSTUVWXYZ
WDR5Wnt SignalingFeatured New Products7645 | FHT 2344强效 SMARCA2/4 抑制剂7892 |用于标记突变体 FKBP12F36V 蛋白的 dTAG-荧光素荧光探针7368 | Cell Counting Kit-8细胞活力及增殖检测试液7842 | NAMPT PROTAC® A7强效选择性烟酰胺磷酸核糖转移酶降解剂7898 | ZZL 7 SERT 和 nNOS 之间相互作用的抑制剂我们如何帮助您？
关闭开始聊天Description: Very selective, high affinity A2A antagonist Chemical Name: 2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine Purity: ≥99% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferencesBiological Activity
Selective adenosine A2A receptor antagonist; binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively). Displays > 23000-fold selectivity for hA2A over hA1 in vitro with minimal affinity for hA2B and hA3 receptors (IC50 > 10 μM). Blocks the cytoprotective effect of A2A agonist CGS-21680 (Cat.No. 1063).
Technical Data
| M. Wt | 389.42 |
| Formula | C20H19N7O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 316173-57-6 |
| PubChem ID | 10668061 |
| InChI Key | AEULVFLPCJOBCE-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(CCCN2N=CC3=C2N=C(N)N2N=C(N=C32)C2=CC=CO2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 38.94 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 389.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Todde et al (2000) Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A2A receptor system using positron emission tomography. J.Med.Chem. 43 4359 PMID: 11087559
Zheng et al (2007) Protective roles of adenosine A1, A2, and A3 receptors in skeletal muscle ischemia and reperfusion injury. Am.J.Physiol.Heart Circ.Physiol. 293 3685 PMID:
Keywords: SCH 442416, supplier, selective, high, affinity, A2A, antagonists, Receptors, adenosines, SCH442416, adenosine, 2a, antagonist, Adenosine, A2A, Receptors, Adenosine, A2A, Receptors, Tocris Bioscience
