Abstract #976: Gastric cardia adenocarcinoma in Chinese: Histopathological analysis on 7301 patients from Linxian and nearby counties, the high risk area in Henan, Northern China. | Cancer Research Abstract #976: Gastric cardia adenocarcinoma in Chinese: Histopathological analysis on 7301 patients from Linxian and nearby counties, the high risk area in Henan, Northern China. Li Dong Wang, Yan Wang, Ji Lin Li, Xue Ke Zhao, Sheng Li Zhou, Guo Qiang Kong, Hai Yan Wang, Zhi Min Zhao, Dong Mei Fan, Yi Yuan, Yong Hong Ai, Jie Zhi Yang, Zhi Qiang Sun, Xing Chuan Li, Jin Ya Tian, Yan Jin, Qin Lu, Xue Min Li, Song Liang Qiu and Jing Li RenLi Dong Wang 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteYan Wang 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteJi Lin Li 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteXue Ke Zhao 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteSheng Li Zhou 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteGuo Qiang Kong 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteHai Yan Wang 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteZhi Min Zhao 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteDong Mei Fan 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteYi Yuan 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteYong Hong Ai 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteJie Zhi Yang 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteZhi Qiang Sun 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteXing Chuan Li 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteJin Ya Tian 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteYan Jin 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteQin Lu 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteXue Min Li 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteSong Liang Qiu 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteJing Li Ren 1Henan Key Lab for Esophageal Cancer Res, Zhengzhou Univ, Zhengzhou, Henan, China; 2Dept of Pathol, Yaocun Esophageal Cancer Hospital, Linzhou, Henan, China; 3Cancer Res Center, Xinxiang Med College, Xinxiang, Henan, China; 4Dept of Internal Medicine, Henan University, Kaifeng, Henan, China; 5Dept of Pathol, Cixian Hospital, Cixian, Hebei, ChinaFind this author on Google ScholarFind this author on PubMedSearch for this author on this site AACR Annual Meeting-- Apr 18-22, 2009; Denver, COAbstractLinxian and nearby counties in Henan, Northern China have been well documented as the highest incidence area for esophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA). Historically, because of the similar dysphagia symptom, GCA has been categoried as esophageal cancer (EC), and in the past decades, GCA has not been well characterized in histopathological changes in these high risk areas. The present study was thus undertaken to analyse the histopathological changes in gross morphology, location, TNM staging and, especially the intestinal metaplasia (IM) in GCA from the patients in Linxian and nearby counties. 7301 cases with GCA were enrolled for this study, including 5621 males with a mean age of 59±9 (mean±SD) and 1680 females with a mean age of 58±9. Consecutive tissue embedding with paraffin was applied for the whole surgical specimen. Based on the gross changes, GCA was classified into three major types, i.e.: infiltrating, ulcer and fungating, and the percentage of the three gross types was 47%, 41%, 12%, respectively in male and 52%, 36%, 12%, respectively in female. There was no significant difference in gross type in gender. Histopathological examination showed that IM was identified in 26% of the GCA specimen examined. The predominant type of IM was type I (71%), followed by type II (23%), and type III (7%) (P 0.05). TNM staging showed that, of the 1485 GCA with clear TNM record after surgical resection, 42% in stage II, 55% in stage III-IV and less than 3% of GCA patients was diagnosed at early stage (TNM staging 0, I). Based on the chief location of GCA with relation to Z line, GCA was classified into different location types, i.e. type A (all the tumor was located under Z line without assaulting any esophageal squamous epithelium), type B (2/3 of the tumor under Z line), type C (half of the tumor under the Z line), type D (1/3 of the tumor under Z line), type E (all the tumor above Z line), and type F (indefinite, because of the Z line destroyed and replaced by cancer tissue). In the present study, the predominant location types (81%) for GCA was type A (33%) and B (48%), followed by type C (9%), D (6%), F (4%) and E (0.4%). The present studies demonstrate that the predominant anatomic gross type for GCA is infiltrating type, 26% of GCA occurs IM with a majority of type I, and 81% of GCA is located chiefly on the cardia side in Chinese patients, which indicates that more than 90% of GCA in Chinese may be #8220;true gastric cardia cancer#8221;, which is quite different with Western pattern in tissue origination and IM.Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 976.Footnotes100th AACR Annual Meeting-- Apr 18-22, 2009; Denver, COAmerican Association for Cancer Research Thank you for sharing this Cancer Research article.NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses. Message Body (Your Name) thought you would be interested in this article in Cancer Research.CAPTCHAThis question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Abstract #976: Gastric cardia adenocarcinoma in Chinese: Histopathological analysis on 7301 patients from Linxian and nearby counties, the high risk area in Henan, Northern China. Li Dong Wang, Yan Wang, Ji Lin Li, Xue Ke Zhao, Sheng Li Zhou, Guo Qiang Kong, Hai Yan Wang, Zhi Min Zhao, Dong Mei Fan, Yi Yuan, Yong Hong Ai, Jie Zhi Yang, Zhi Qiang Sun, Xing Chuan Li, Jin Ya Tian, Yan Jin, Qin Lu, Xue Min Li, Song Liang Qiu and Jing Li Ren Cancer Res May 1 2009 (69) (9 Supplement) 976; Abstract #976: Gastric cardia adenocarcinoma in Chinese: Histopathological analysis on 7301 patients from Linxian and nearby counties, the high risk area in Henan, Northern China. Li Dong Wang, Yan Wang, Ji Lin Li, Xue Ke Zhao, Sheng Li Zhou, Guo Qiang Kong, Hai Yan Wang, Zhi Min Zhao, Dong Mei Fan, Yi Yuan, Yong Hong Ai, Jie Zhi Yang, Zhi Qiang Sun, Xing Chuan Li, Jin Ya Tian, Yan Jin, Qin Lu, Xue Min Li, Song Liang Qiu and Jing Li Ren Cancer Res May 1 2009 (69) (9 Supplement) 976; Cancer Research Print ISSN: 0008-5472Journal of Cancer Research ISSN: 0099-7013American Journal of Cancer ISSN: 0099-7374