Advanced Materials TechnologiesVolume 2, Issue 11 1700022 Progress Report Advanced Biotechnologies Toward Engineering a Cell Home for Stem Cell Accommodation Bei-Min Tian, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorXiao-Tao He, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorXin-Yue Xu, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorXuan Li, National Clinical Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorRui-Xin Wu, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. China National Clinical Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. China Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Biomaterials Unit, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorFa-Ming Chen, Corresponding Author cfmsunhh@fmmu.edu.cn State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. China National Clinical Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. China Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Biomaterials Unit, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaE-mail: cfmsunhh@fmmu.edu.cnSearch for more papers by this author Bei-Min Tian, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorXiao-Tao He, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorXin-Yue Xu, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorXuan Li, National Clinical Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorRui-Xin Wu, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. China National Clinical Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. China Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Biomaterials Unit, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaSearch for more papers by this authorFa-Ming Chen, Corresponding Author cfmsunhh@fmmu.edu.cn State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. China National Clinical Research Center for Oral Diseases, Department of Periodontology, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. China Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Biomaterials Unit, School of Stomatology, Fourth Military Medical University, 710032 Xi\'an, P. R. ChinaE-mail: cfmsunhh@fmmu.edu.cnSearch for more papers by this author Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URLShare a linkShare onEmailFacebookTwitterLinked InRedditWechat Biomaterials that exhibit bioinspired behavior enable a range of novel biomedical applications. Cell-friendly biomaterials incorporating crucial physicochemical cues can instruct and dictate cell behavior both in vitro and in vivo. Despite substantial advances, engineering a complex cell regulatory system that incorporates mechanical and chemical signals targeting specific intracellular events has remained far from a reality. Recently, biological studies have begun to decipher the dynamic interplay between stem cells and their microenvironments. Moreover, the myriad recently developed advanced material biotechnologies, such as 3D bioprinting, protein engineering, release technology, high-throughput screening, and microfluidics, have enabled the engineering of sophisticated biomaterial systems that increasingly closely mimic the spatial and temporal characteristics of the native cell milieu. Thus, biomaterials engineered in the laboratory not only provide a fertile environment for fostering stem cells but also exhibit properties that elicit favorable crosstalk between the structural components, the cells and the host tissue in a precise physiological manner, enabling balanced matrix generation and degradation for successful tissue regeneration to be achieved. This progress report discusses these advanced biotechnologies for the design, fabrication, and functionalization of biomaterials, highlighting their merits over traditional methodologies for mimicking the structural and mechanical properties of their natural in vivo counterparts. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Please check your email for instructions on resetting your password. If you do not receive an email within 10 minutes, your email address may not be registered, and you may need to create a new Wiley Online Library account. Can\'t sign in? 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