首页 > DiscoverX > DiscoverX/PathHunter® PD-1 (SHP1) Signaling Bioassay Kit/1000dp(10x96-well)/93-1104Y19-00118

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DiscoverX/PathHunter® PD-1 (SHP1) Signaling Bioassay Kit/1000dp(10x96-well)/93-1104Y19-00118

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The PathHunter PD1 Signaling Bioassay consists of human cells engineered to stably express an ED-tagged immune checkpoint receptor, PD-1, while EA is fused to either the full length or the phosphotyrosine-binding SH2 domain of an intracellular signaling protein, SHP1. Engagement of the receptor by its ligand, or agonist antibodies results in phosphorylation of the receptor’s cytosolic tail. The SH2-domain fused to EA binds the phosphorylated receptor, forcing complementation of ED and EA, resulting in formation of an active β-gal enzyme, which hydrolyzes the substrate to generate a chemiluminescent signal.The bioassay kit contains all reagents needed for the assay including pre-qualified cryopreserved cells, detection reagents, cell plating reagent, positive control agonist, and assay plates.Target/DescriptionProgrammed cell death protein 1GroupT cell receptor (inhibitory)SH2 DomainSHP1Cell BackgroundJurkatSpeciesHumanAccession NumberNM_005018.2Agonist/LigandAnti-PD1 Antibody [NAT105]Antagonist/InhibitorAnti-PD1 antibody [NAT105]Assay MeasuresSH2 RecruitmentBioassay Target NamePD-1 Assay Qualified WithKeytruda® Drug Trademark OwnerKeytruda®is a registered trademark of Merck & Co., Inc. How it worksThe graph is an example of a typical dose-response curve for the PD-1 Signaling Bioassay, generated usingthe protocol outlined in this user manual. The data shows a potent, dose-dependent inhibition of PD-1 activation in Jurkat cells with an anti-PD-1 antibody.

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