首页 > DiscoverX > DiscoverX/PathHunter® Tocilizumab Bioassay Kit/200dp(2x96-well)/93-1045B3-00109

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DiscoverX/PathHunter® Tocilizumab Bioassay Kit/200dp(2x96-well)/93-1045B3-00109

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The PathHunter Tocilizumab Bioassay is an application of the DiscoverX Dimerization Assay platform. The assay is designed to detect the ligand-induced interaction of the interleukin-6 receptor (IL-6R) with the interleukin-6 signal transducer protein (IL-6ST). The cells have been engineered to co-express IL-6ST fused to PK, and IL-6R fused to EA. Binding of an agonist to the IL-6R causes multimerization of the IL-6R and IL-6ST receptors, resulting in activation of downstream signaling events. This brings the two b-gal fragments into close proximity, forcing complementation. Heterodimerization of the two receptor chains results in the formation of a functional b-gal enzyme that hydrolyzes the substrate to generate a chemiluminescent signal. Blocking IL-6 binding with an anti-ligand or anti-receptor antibody can prevent this interaction, resulting in a loss of signal.The bioassay kit contains all reagents needed for the assay, including pre-qualified cryopreserved cells, detection reagents, cell plating reagent, positive control agonist, and assay plates.Target/Descriptioninterleukin 6 receptor GroupInterleukin ReceptorCell BackgroundU2OSSpeciesHumanAccession NumberNM_000565.3Agonist/LigandIL-6Assay MeasuresDimerizationBioassay Target NameIL6R/IL6ST Assay Qualified WithActemraDrug Trademark OwnerActemra is a registered trademark of Chugai Seiyaku Kabushiki Kaisha Corp., a member of the Roche Group. How it works

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苏州蚂蚁淘实验试剂有限公司DiscoveRx专业代理，具体产品信息欢迎电询：

DiscoveRx 公司一家以提供包括 G 蛋白耦联受体，激酶，NHR 和蛋白酶创新型细胞实验方法的主要供应商。DiscoveRx’s PathHunter(TM) beta-Arrestin 和 HitHunter(TM) cAMP assays 是均相化学发光探测实验，该种实验平台已经迅速成为药物临床前研发中利用G蛋白耦联受体筛选分析药物的平台。
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