首页 > Diapharma > Diapharma/Chromogenix Coatest® SP4 Factor VIII/K824094/Kit/200 tests

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Diapharma/Chromogenix Coatest® SP4 Factor VIII/K824094/Kit/200 tests

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Description:ChromogenixCoatest®SP4FactorVIIIisachromogenicassaykitfortheinvitrodiagnosticphotometricdeterminationoffactorVIIIactivityincitratedplasma.KitComposition:Reagents,Packaging,Storage,StABIlity,andMicroplate/TestTubePreparationS-2765™15.4mg+I-2581,1vial.Chromogenicsubstrate(N-a-Z-D-Arg-Gly-Arg-pNA),15.4mg,syntheticthrombininhibitor,0.4mg,andmannitoladdedasabulkingagent.Reconstitutewith12.0mLofsterilewaterorNCCLStypeIIwater,toobtainaconcentrationof2.7mmol/L.Stabilityafterreconstitution:3monthsat2-8°C.FactorIXa+factorX2.7IU,4vials.LyophilizedbovinefactorsIXaandXwithbovinealbuminaddedasastabilizingagent.Reconstitutewith3.0mLofsterilewaterorNCCLStypeIIwater.Stabilityafterreconstitution:12hoursat2-8°C.Thesolutioncanbestoredfrozeninaliquotsat-20°C(oratlowertemperature)for3months.Donotrefreeze.CaCl26ml,1vial.Calciumchloridesolution,0.025mol/LReadytouse.Openedvialisstable3monthsat2-8°C.Buffer,stocksolution20mL,1vial.20mLconcentratedTrisbuffercontainingNaClandBSA.Characteristicsoftenfolddilutedbuffer:Tris0.05mol/L,pH7.3,10mg/LCiprofloxacinand1.0%BSA.Dilute1:10(1+9)withsterilewaterorNCCLStypeIIwater.Prepareanewbufferworkingsolutioneachday.Onceopenedthebuffer.Phospholipid2mL,1vial.Mixtureofhighlypurifiedphospholipidsand10mg/LCiprofloxacin.Readytouse.Openedvialisstablefor3monthsat2-8°C.Shakegentlybeforeuse.Whenkeptat2-8°Cthesealedreagentsarestableuntiltheexpirydateprintedonthelabel.Contaminationbymicroorganismsshouldbeavoidedoncethevialsareopened.MeasurementPrinciple:FIXa,Ca2+,phospholipidFactorX→FXaFVIIIFXaS-2765™→Peptide+pNAInthepresenceofcalciumandphospholipids,factorXisactivatedtofactorXabyfactorIXa.ThisgenerationisgreatlystimulatedbyfactorVIII,whichmaybeconsideredasacofactorinthisreaction.ByusingoptimalamountsofCa2+andphospholipidsandanexcessoffactorsIXaandX,therateofactivationoffactorXissolelydependentontheamountoffactorVIII.FactorXahydrolysesthechromogenicsubstrateS-2765™thusliberatingthechromophoricgroup,pNA.Thecoloristhenreadphotometricallyat405nm.ThegeneratedfactorXaandthustheintensityofcolorisproportionaltothefactorVIIIactivityinthesample.HydrolysisofS-2765™bythrombinformedispreventedbytheadditionofthesyntheticthrombininhibitor,I-2581,togetherwiththesubstrate.Background:FactorVIIIisanon-enzymaticplasmaproteinthatisessentialfornormalbloodcoagulation. ThedeficiencyoffactorVIIIactivityinhumansisassociatedwithacongenitalbleeding disorder,calledhemophiliaA,whichaffectsabout1in5000males.HemophiliaApatients aretreatedwithfactorVIIIconcentrateformaintenanceofnormalhemostasisbut regrettablyprophylactictreatmentisnotingeneraluseworldwide.Duringlateryears recombinantfactorVIIIhasbeenapprovedfortherapeuticuse,whichminimizestherisk ofviraltransmission.ThereisnowalsogrowingevidencethatelevatedfactorVIIIactivity isariskfactorforthrombosis.Hence,factorVIIIlevelsareofimportancetomeasurenot onlyfordiagnosingandmonitoringhemophiliaAbutalsoforthrombophiliainvestigations. Withtheadventofchromogenicsubstratetechnologyaccurateandsensitivemethodsare availableforqualitycontrolandfortheclinicalcoagulationlaboratory.Itisthepurposeof thismonographtopresentanoverviewofbiochemicalandclinicaldataonfactorVIIIand toprovidecomprehensiveinformationonmethodologicalaspectsandontheuseofthe Coamatic®andCoatest®FactorVIIIkits.ReadmoreaboutchromogenicdeterminationofFactorVIII…

Diapharma使命宣言

位于俄亥俄州西切斯特的Difarma Group，Inc.在诊断和研究领域销售止血、血栓形成、血小板功能测试、仪器和凋亡产品，并提供强大的技术能力和经验，以确保满足或超过客户的期望。

地黄止血显色凝块酶联免疫吸附试验试剂盒

历史

1997年1月1日，由俄亥俄州富兰克林市的Pharmacia Hepar，Inc.成立，最初是Chromogenix基质和分析的独家美国和加拿大经销商。

四分之一个多世纪前，Chromogenix开发了第一个显色底物技术，其前身是Kabi Diagnostica。卡比后来与法玛西亚合并。希帕玛目前的一些员工在法玛西亚肝素制造厂的显色部门工作。

1998年，夏帕玛搬到了俄亥俄州的西切斯特，至今仍在那里。多年来，迪法玛扩大了其产品线，包括各种止血、细胞死亡、血小板功能、生态毒理学、化验、试剂、抗体和高级制造商的仪器。

2017年，夏帕玛庆祝了20年的成功