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TASP-0415914

Chemical

C13H17N5O3S

323.4

1292300-75-4

≥95%

Solid.

Soluble in DMSO.

Manufactured by SynKinase.

Target: PI3KγClick here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

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AMBIENT

+4°C

+4°C

Stable for at least 1 year after receipt when stored at +4°C.

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PI3Kγ is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Kγ IC(50) 29nM, AKT IC(50) 294nM.Product References

Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases: Y. Oka, et al.; Bioorg. Med. Chem. 21, 7578 (2013)