BackgroundDNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

DescriptionAPOBEC3A Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

SpecificityHuman

IsotypeIgG

Uniprot IDP31941

Purification>95%, Protein G purified

ImmunogenRecombinant human DNA dC->dU-editing enzyme APOBEC-3A protein (1-199AA)

StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative NamesDNA dC->dU-editing enzyme APOBEC-3A (EC:3.5.4.-), A3A, APOBEC3A, Phorbolin-1

ApplicationELISA

VCU0006