- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Camptothecin is a quinolone alkaloid precursor of irinotecan; it is originally produced by Camptotheca. Camptothecin exhibits anticancer chemotherapeutic activity, inhibiting topoisomerase I and inducing double-stranded DNA breaks. Camptothecin is extremely cytotoxic and only its derivatives are clinically used as chemotherapeutics.
Product Info
7689-03-4 |
≥98% |
C20H16N2O4 |
348.35 |
(S)-4-Ethyl-4-hydroxy-1H-pyrano[3,4:6,7]indolizino- [1,2-b]quinoline-3,14(4H,12H)-dione |
264-267°C(dec.) |
Soluble in DMSO. |
Pale yellow crystalline powder |
Shipping and Storage
-20°C |
Ambient |
Downloads
C0150 MSDS PDF |
C0150 Info Sheet PDF |
References
Rodríguez-Berna G, Mangas-Sanjuán V, Gonzalez-Alvarez M, et al. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Eur J Med Chem. 2014 Jun 25;83C:366-373. PMID: 24980118.
Berniak K, Rybak P, Bernas T, et al. Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A. 2013 Jul 11. [Epub ahead of print]. PMID: 23846844.
Redinbo MR, Stewart L, Kuhn P, et al. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science. 1998 Mar 6;279(5356):1504-13. PMID: 9488644.
