IrinoTECAN Chemical Properties,Uses,Production Uses Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively Definition ChEBI: A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4\'-bipiperidine]-1\'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydroy-1H-pyrano[3\',4\':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoa of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. brand name Camptosar (Pharmacia &Upjohn) Irinotecan Preparation Products And Raw materials Raw materials Related articles Medical uses, Mechanism and Toxicities of IrinotecaIrinotecan, sold under the brand name Camptosar among others, is an antineoplastic enzyme inhibitor primarily used in the trea....Nov 14，2019 1,4\'-Bipiperidine-1\'-carboxylic acid (S)-4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3\',4\':6,7]indolizino[1,2-b]quinolin-9-yl ester DQ-2805 (4S)-4,11-Diethyl-4-hydroxy-9-[[(4-piperidinopiperidino)carbonyl]oxy]-3,4,12,14-tetrahydro-1H-pyrano[3\',4\':6,7]indolizino[1,2-b]quinoline-3,14-dione SN-38-11 (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate [1,4\'-Bipiperidine]-1\'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3\',4\':6,7]indolizino[1,2-b]quinolin-9-yl ester, (S)- 1H-Pyrano[3\',4\':6,7]indolizino[1,2-b]quinoline, [1,4\'-bipiperidine]-1\'-carboxylic acid deriv. Irinotecan base Irinotecanum Irinotecan Monomer Irinotecan EP Impurity L (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3\',4\':6,7]indolizino[1,2-b]quinolin-9-yl-[1,4\'-bipiperidine]-1\'-carboxylic acid (s)-[1,4\'-bipiperidine]-1\'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3\',4\':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3\',4\':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER Irinotecan Labeled d10 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3\',4\':6,7]indolizino[1,2- TOPOTECIN HYDROCHLORIDE [1,4\'-BIPIPERIDINE]-1\'-CARBOXYLIC ACID CPT-11 IRINOTECAN IRINOTECAN HCL CAMPTOSAR CAMPTOTHECIN 11 HYDROCHLORIDE CAMPTOTHECIN 11 HYDROCHLORIDE,TOPOTECIN Irinotecan(Cpt-11) (1,4\'-Bipiperidine)-1\'-carboxylicacid(S)-4,11-di] Irinotecane [1,4\'-Bipiperidine]-1\'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3\',4\':6,7]indolizino[1,2-b]quinolin-9-yl ester IRINOTECAN HCL(P) [1,4\'-Bipiperidine]-1\'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3\',4\':6,7]indolizino[1,2-b]quinolin-9-yl ester (9CI) (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3\',4\':6,7]indolizino[1,2-b]quinolin-9-yl [1,4\'-bipiperidine]-1\'-carboxylate Irinotecan USP/EP/BP 97682-44-5 97682-44-8 C33H38N4O6 Camptothecin series APIs Natural Anti-cancer Medical Materials and It\'s Derivatives API\'s chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Anti cancer Inhibitors Camptosar, Campto Anti-cancer&immunity +Add Attachment (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB)