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   Detection of human Formin-like 1 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Formin-like 1 antibody A304-869A (lot A304-869A-1) used for IP at 6 µg per reaction. Formin-like 1 was also immunoprecipitated by rabbit anti-Formin-like 1 antibody BL18970. For blotting immunoprecipitated Formin-like 1, A304-869A was used at 1 µg/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

The Formin-like protein 1 (FRL1) gene encodes a formin-related protein which has been implicated in morphogenesis, cyokinesis, and cell polarity. Formins are a conserved class of proteins expressed in all eukaryotes and have one DAD (diaphanous autoregulatory domain), one FH2 (formin homology 2) domain and one GBD/FH3 (Rho GTPase-binding / formin homology 3) domain. FRL1 is located in the cytoplasm and is highly expressed in the spleen, lymph node and bone marrow cells. FRL1 possibly has a role in the control of cell motility, survival of macrophages and cytoskeletal organization.

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蛋白别名: CLL-associated antigen KW-13; formin-like 1; Formin-like protein 1; Leukocyte formin
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