330022 | WR304 mAb-biotinylated WR304 Mouse Monoclonal Antibody (IgM), BiotinylatedAnti-(PIP/PIP2) Please Confirm Your Location

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*The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada

Custom Packaging (${custompackaging} @ $4 per aliquot): ${custompackagingperunit|money} Custom packaging is calculated at $4.00 per aliquot + $100.00 surcharge.For all other custom packaging options not listed above, please contact us for a quote WR304 mAb-biotinylated WR304 Mouse Monoclonal Antibody (IgM), BiotinylatedAnti-(PIP/PIP2) WR304 is an antibody that binds specifically to the lipids PIP andPIP2. WR304 also neutralizes infectious HIV-1 virus and can be used to probe the presence of PIP and PIP2 in membranes in a variety of applications including inositol phosphate-dependent cell signaling pathways.WR304-Biotin allows this antibody to be used in combination with a wide range of commercially available streptavidin-fluorophore and streptavidin-enzyme complexes. WR304-Biotin can also be used with samples that contain mouse IgM.This antibody was developed by the Walter Reed Army Institute of Research (WRAIR) using a targeted adjuvant protocol with liposomes containing Avanti’s Lipid A. Storage Temperature The recommended long-term storage for WR304 is at -80°C. After initial thawing remaining product should refrozen at -80°C.

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PubMed ID: 6095072

Matyas GR, Beck Z, Karasavvas N, Alving CR. Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1. Biochim Biophys Acta. 2009 Mar;1788(3):660-5. doi: 10.1016/j.bbamem.2008.11.015. Epub 2008 Dec 3. PMID: 19100711.

PubMed ID: 19100711

Brown BK, Karasavvas N, Beck Z, Matyas GR, Birx DL, Polonis VR, Alving CR. Monoclonal antibodies to phosphatidylinositol phosphate neutralize human immunodeficiency virus type 1: role of phosphate-binding subsites. J Virol. 2007 Feb;81(4):2087-91. doi: 10.1128/JVI.02011-06. Epub 2006 Dec 6. PMID: 17151131; PMCID: PMC1797582.

PubMed ID: 17151131

Beck Z, Karasavvas N, Tong J, Matyas GR, Rao M, Alving CR. Calcium modulation of monoclonal antibody binding to phosphatidylinositol phosphate. Biochem Biophys Res Commun. 2007 Mar 16;354(3):747-51. doi: 10.1016/j.bbrc.2007.01.033. Epub 2007 Jan 16. PMID: 17257584.

PubMed ID: 17257584