.safetyRow { clear: both; } .safetyLeft { width: 210px; float: left; }Synonym: Polymyxin B sulfate salt CAS Number 1405-20-5 Empirical Formula (Hill Notation) C55H96N16O13 · 2H2SO4 Molecular Weight 1385.61  EC Number 215-774-7  MDL number MFCD00131991 Popular Documents:  Specification Sheet (PDF)   Properties: Related Categories Analytical/Chromatography, Antibacterial, Antibiotic powders, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Biochemicals and Reagents, Cell Culture, Chemical Structure Class, Core Bioreagents, Interferes with Cell Membrane Permeability (Ionophores), L - Z, Mechanism of Action, Peptides, Pharmacopoeia, Pharmacopoeia A-Z, Pharmacopoeial Antibiotics, Reagents and Supplements, Research Essentials, Spectrum of Activity More... form   powder solubility   H2O: 50 mg/mL (Stock solutions should be filter sterilized and stored at 2-8 °C. Stable at 37 °C for 5 days.) suitability   meets USP testing specifications Mode of action   cell membrane | interferes storage temp.   2-8°C Description: Frequently Asked Questions Frequently Asked Questions are available for this Product. Application Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots. Biochem/physiol Actions Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria. Caution As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days. Packaging This product is packaged in a bottomless glass bottle, with its contents inside an inserted fused cone. Preparation Note Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol. Safety: Personal Protective Equipment  dust mask type N95 (US), Eyeshields, Gloves RIDADR  NONH for all modes of transport WGK Germany  3 RTECS  TR1150000