用途及描述：科研试剂，广泛应用于分子生物学，药理学等科研方面。本品为细胞诱导分化药。维A酸是维生素A的代谢中间体，主要影响骨的生长与上皮代谢。通过调节表皮细胞的有丝分裂和表皮细胞的更新，促进正常角化，影响上皮代谢，对上皮角细胞的生长和角质层的脱落有明显的促进作用，可促使已有的粉刺去除，同时又抑制新的粉刺；可阻止角质栓的堵塞，对角蛋白的合成有抑制作用。

InChI Key SHGAZHPCJJPHSC-YCNIQYBTSA-Nassay 98% (HPLC)form powdercolor yellowmp 180-181 C(lit.)storage temp. 20 C

Retinoic acid (RA) has been used for the differentiation of embryonic stem cells into motor neurons.[1] It has been used for the differentiation of Xenopus ectoderm into pancreas.[2] It has also been used to study epigenetic regulation by RAR (retinoic acid receptor ).[3] It has been used to study RA signaling of prospermatogonia transition into spermatogonia.[4]

Biochem/physiol Actions

all trans Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Features and Benefits

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This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

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