首页 > Biolegend > Biolegend/Recombinant Human MIF carrier-free/25 µg/599404

提醒：代购产品，无质量问题不接受退换货，下单前请仔细核对信息。下单后请及时联系客服核对商品价格，订单生效后再付款。

Biolegend/Recombinant Human MIF carrier-free/25 µg/599404

价格：

登录查看

自营商城

解放采购

正品保障

及时交付

厂家直采

一站服务

货号：

599404

品牌：

Biolegend

会员服务：

尊享会员价

贵宾专线

运费优惠

闪电退款

福利优惠

上门换新

友情提示

以上价格仅为参考，请联系客服询价。

免费咨询热线

4000-520-616

产品说明

DescriptionMIFwasdiscoveredinthe1960’sasaT-lymphocyteproductthatinhibitstherandommigrationofmacrophagesduringdelayed-typehypersensitivityresponses.Thiscytokineisasingle,non-glycosylated,115aminoacidspolypeptidethathasaβ-α-βmotif.ItisknownthatMIFinducesinflammatorycytokines,nitricoxideandsuperoxideanions,andregulatesmacrophageandlymphocyteproliferation.TheimmunoregulatoryactivitiesofMIFarebasedupontranscriptionalregulationofinflammatorygeneproducts,modulationofcellproliferationandcellcycleinhibitionofp53-mediatedapoptosis,andanumberofmetaboliceffects.MIFalsodemonstratesbroadregulatorypropertiesandisconsideredasacriticalmediatorofmultipledisorders,includinginflammatoryandautoimmunediseasessuchasrheumatoidarthritis,glomerulonephritis,diabetes,atherosclerosis,sepsis,asthma,andacuterespiratorydistresssyndrome.FurThermore,studieshavehighlightedtheroleofMIFintumOrigenesis.Humancancertissues,includingskin,brain,breast,colon,prostate,andlung-derivedtumorsoverexpressMIF;MIFlevelscorrelatedwithtumoraggressivenessandmetastaticpotential.Therefore,MIFisconsideredaviabletherapeutictargetfortreatinginflammatorydiseasesandneoplasia.Inadditiontoitsphysiologicandpathophysiologicactivities,MIFisknowntoactasatautomeraseandhasacatalyticallyactiveN-terminalprolinethatisinvariantinstructurallyhomologousbacterialisomerases.AlthoughtherelationshipbetweenthecatalyticactivityandBIOLOGicalfunctionofMIFisnotyetfullyunderstood,targetingMIFtautomeraseactivityusingsmall-moleculeinhibitorshasemergedasanattractivestrategyforinhibitingMIFproinflammatoryactivityandattenuatingitsbiologicalactivityinvitroandinvivo.HumanandmouseMIFsharea90%homology.ProductDetails

美国BioLegend公司是世界著名的流式抗体生产商之一。BioLegend聚集了一批来自BD PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以最合理的价格为生物医药研究的各个前沿领域提供高质量的抗体、试剂盒及其他相关产品