- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Thapsigargin is a sesquiterpene lactone found in Thapsia that is used in research models to induce endoplasmic reticulum (ER) stress. Thapsigargin inhibits SERCA Ca2+ pumps and may induce autophagy or apoptosis.
Product Info
67526-95-8 |
≥96% |
C34H50O12 |
650.75 |
Octanoic acid, 6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-((2- methyl-1-oxo-2-butenyl)oxy)-2-oxo-4-(1-oxobutoxy)- azuleno(4,5-b)furan-7-yl ester, (3S-(3α,3aβ,4α,6β,- 6aβ,7β,8α(Z),9bα))- |
[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate |
Thapsigargine; Tg |
Soluble in DMSO, ethanol, or acetonitrile. |
Colorless film |
Shipping and Storage
-20°C |
Ambient |
Downloads
T2801 MSDS PDF |
T2801 Info Sheet PDF |
References
Zhang X, Yuan Y, Jiang L, et al. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014 Oct 1;10(10):1801-13. PMID: 25126734.
Wang H, Jia XZ, Sui CJ, et al. Effects of thapsigargin on the proliferation and survival of human rheumatoid arthritis synovial cells. ScientificWorldJournal. 2014 Feb 9;2014:605416. PMID: 24688409.
Rogers TB, Inesi G, Wade R, et al. Use of thapsigargin to study Ca2+ homeostasis in cardiac cells. Biosci Rep. 1995 Oct;15(5):341-9. PMID: 8825036.
