Product overview

• NameL-NAME
• Short descriptionNon-selective NOS inhibitor
• Biological descriptionNon-selective nitric oxide synthase (NOS) inhibitor. Also inhibits cyclic GMP (IC₅₀ = 3.1 μM). Methyl ester pro-drug of L-NNA. Displays hypertensive properties.
• Biological actionInhibitor
• Purity>98%
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Properties

• Chemical nameNomega-Nitro-L-arginine methyl ester hydrochloride
• Molecular Weight269.69
• Chemical structure
• Molecular FormulaC₇H₁₅N₅O₄.HCl
• CAS Number51298-62-5
• PubChem identifier135193
• SMILESCOC(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])N.Cl
• InChiInChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
• InChiKeyQBNXAGZYLSRPJK-JEDNCBNOSA-N
• MDL numberMFCD00039052

Storing and Using Your Product

• Storage instructionsRoom temperature
• Solubility overviewSoluble in water (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for L-NAME

• L-NAME in the cardiovascular system - nitric oxide synthase activator?

  Kopincová J et al (2012)Pharmacol Rep 64(3) : 511-20. PubMedID: 22814004

• Nitric oxide synthases: structure, function and inhibition.

  Alderton WK et al (2001)Biochem J 357(Pt 3) : 593-615. PubMedID: 11463332

• Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.

  Rees DD et al (1990)Br J Pharmacol 101(3) : 746-52. PubMedID: 1706208