Product overview
- NameLY367385
- Short descriptionPotent, highly selective mGlu1a antagonist
- Biological description
Potent, highly selective and competitive mGlu1a receptor antagonist (IC50 = 8.8 μM for blockade of quis-induced phosphoinositide (PI) hydrolysis, compared with >100μM for mGluR5 mediated responses).
Impairs induction and late phases of both long term potentiation (LTP) and long term depression (LTD) when applied before high-frequency tetanization (HFT) or low-frequency stimulation (LFS).
Also displays antidepressant, anticonvulsant and neuroprotective actions.
- Biological actionAntagonist
- Purity>98%
- Our products in action2 citationsSubmit Your Citation Now
Images
Properties
- Chemical name(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid
- Molecular Weight209.2
- Chemical structure
- Molecular FormulaC10H11NO4
- CAS Number198419-91-9
- PubChem identifier5311261
- SMILESCC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N
- SourceSynthetic
- InChiInChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h4-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
- InChiKeySGIKDIUCJAUSRD-QMMMGPOBSA-N
- MDL numberMFCD02262124
- AppearanceOff-white solid
Storing and Using Your Product
- Storage instructionsRoom temperature (desiccate)
- Solubility overviewSoluble in 0.1M NaOH (100mM)
- ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for LY367385
Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).
Chapman AG et al (1999)Eur J Pharmacol 368(1) : 17-24. PubMedID: 10096765Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept
Bruno V et al (1999)Neuropharmacology 38(2) : 199-207. PubMedID: 10218860Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.
Car H et al (2006)Pharmacol Rep 58(5) : 758-64. PubMedID: 17085869Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
Neyman et al (2008)Eur J Neurosci 27(6) : 1345-52 PubMedID: 18364018