Product overview

• NameLY367385
• Short descriptionPotent, highly selective mGlu_1a antagonist
• Biological description

  Potent, highly selective and competitive mGlu_1a receptor antagonist (IC₅₀ = 8.8 μM for blockade of quis-induced phosphoinositide (PI) hydrolysis, compared with >100μM for mGluR₅ mediated responses).

  Impairs induction and late phases of both long term potentiation (LTP) and long term depression (LTD) when applied before high-frequency tetanization (HFT) or low-frequency stimulation (LFS).

  Also displays antidepressant, anticonvulsant and neuroprotective actions.

• Biological actionAntagonist
• Purity>98%
• Our products in action2 citationsSubmit Your Citation Now

Images

Properties

• Chemical name(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid
• Molecular Weight209.2
• Chemical structure
• Molecular FormulaC₁₀H₁₁NO₄
• CAS Number198419-91-9
• PubChem identifier5311261
• SMILESCC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N
• SourceSynthetic
• InChiInChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h4-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
• InChiKeySGIKDIUCJAUSRD-QMMMGPOBSA-N
• MDL numberMFCD02262124
• AppearanceOff-white solid

Storing and Using Your Product

• Storage instructionsRoom temperature (desiccate)
• Solubility overviewSoluble in 0.1M NaOH (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for LY367385

• Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).

  Chapman AG et al (1999)Eur J Pharmacol 368(1) : 17-24. PubMedID: 10096765

• Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept

  Bruno V et al (1999)Neuropharmacology 38(2) : 199-207. PubMedID: 10218860

• Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.

  Car H et al (2006)Pharmacol Rep 58(5) : 758-64. PubMedID: 17085869

• Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.

  Neyman et al (2008)Eur J Neurosci 27(6) : 1345-52 PubMedID: 18364018