Product overview

• NameDorsomorphin dihydrochloride
• Short descriptionPotent, selective AMPK inhibitor. Also promotes cardiomyocyte differentiation in mouse embroynic stem cells (mESCs).
• Biological descriptionPotent, selective and reversible AMPK inhibitor (K_i = 109 nM). Inhibits AICAR and metformin induced AMPK activation. Additionally shows activity at ALK2, ALK3 and ALK6. Also promotes cardiomyocyte differentiation in mouse embroynic stem cells (mESCs).
• Alternative namesCompound C | BML-275
• Biological actionInhibitor
• Purity>98%
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Properties

• Chemical name6-[4-[2-(1-Piperidinyl)ethoxy]pheny l]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
• Molecular Weight472.41
• Chemical structure
• Molecular FormulaC₂₄H₂₅N₅O.2HCl
• CAS Number1219168-18-9

Storing and Using Your Product

• Storage instructionsroom temperature (desiccate)
• Solubility overviewsoluble in water (100mM) or DMSO (20mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Dorsomorphin dihydrochloride

• Role of AMP-activated protein kinase in mechanism of metformin action.

  Zhou et al (2001)J Clin Invest 108(8) : 1167-74 PubMedID: 11602624

• Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.

  Vucicevic et al (2011)Autophagy 7(1) : 40-50 PubMedID: 20980833

• Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.

  Hao et al (18682835)PLoS One 3(8) : e2904