Product overview

• NameMC 1568
• Short descriptionSelective class IIa HDAC inhibitor
• Biological descriptionSelective class IIa histone deacetylase (HDAC) inhibitor. Inhibits HDAC4 and HDAC5 in the heart and skeletal muscle and suppresses myogenesis. Also inhibits IL-8 expression and promotes neurite growth. Shows neuroprotective, anti-proliferative and anti-cancer actions. Blood-brain barrier permeable.
• Biological actionInhibitor
• Purity>96%
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Properties

• Chemical name3-[5-(3-(3-Fluorophenyl)-3-oxoprope n-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-prope namide
• Molecular Weight314.31
• Chemical structure
• Molecular FormulaC₁₇H₁₅FN₂O₃
• CAS Number852475-26-4

Storing and Using Your Product

• Storage instructions+4°C
• Solubility overviewsoluble in DMSO (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for MC 1568

• Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells.

  Venza I et al (2013)Pigment Cell Melanoma Res 26(2) : 193-204. PubMedID: 23176534

• Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult.

  Collins LM et al (2014)Mol Neurobiol : PubMedID: 25065734

• Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.

  Nebbioso A et al (2009)EMBO Rep 10(7) : 776-82. PubMedID: 19498465