Full text linksSilverchair Information Systems Secretor and Salivary ABO Blood Group AntiGEn Status Predict Rotavirus Vaccine Take in Infants 2 Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. 3 Perinatal Institute, Cincinnati Childrens Hospital Medical Center, Ohio. 4 Vaccine Access and Delivery, PATH, Seattle, Washington. 5 Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Ohio. Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants 2 Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. 3 Perinatal Institute, Cincinnati Childrens Hospital Medical Center, Ohio. 4 Vaccine Access and Delivery, PATH, Seattle, Washington. 5 Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Ohio. Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings. Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US. Armah GE, Cortese MM, Dennis FE, Yu Y, Morrow AL, McNeal MM, Lewis KDC, Awuni DA, Armachie J, Parashar UD. Armah GE, et al. J Infect Dis. 2019 Feb 15;219(5):746-749. doi: 10.1093/infdis/jiy573. J Infect Dis. 2019. PMID: 30357332 Boniface K, et al. J Infect Dis. 2020 Mar 16;221(7):1070-1078. doi: 10.1093/infdis/jiz333. J Infect Dis. 2020. PMID: 31763671 Free PMC article. Pollock L, Bennett A, Jere KC, Dube Q, Mandolo J, Bar-Zeev N, Heyderman RS, Cunliffe NA, Iturriza-Gomara M. Pollock L, et al. Clin Infect Dis. 2019 Sep 27;69(8):1313-1319. doi: 10.1093/cid/ciy1067. Clin Infect Dis. 2019. PMID: 30561537 Free PMC article. Mwila K, et al. Clin Vaccine Immunol. 2017 Jan 5;24(1):e00405-16. doi: 10.1128/CVI.00405-16. Print 2017 Jan. Clin Vaccine Immunol. 2017. PMID: 27847365 Free PMC article. Review. Garg I, Srivastava S, Dogra V, Bargotya M, Bhattar S, Gupta U, Jain S, Hussain J, Hembrom AA, Ghosh N, Kumar V, Kumar B, Varshney R, Ganju L. Garg I, et al. Microb Pathog. 2021 Jun 1;158:105008. doi: 10.1016/j.micpath.2021.105008. Online ahead of print. Microb Pathog. 2021. PMID: 34087389 Free PMC article. Lee B. Hum Vaccin Immunother. 2021 Jun 3;17(6):1787-1802. doi: 10.1080/21645515.2020.1844525. Epub 2020 Dec 17. Hum Vaccin Immunother. 2021. PMID: 33327868 Free PMC article. Review. Loureiro Tonini MA, Pires Gonçalves Barreira DM, Bueno de Freitas Santolin L, Bondi Volpini LP, Gagliardi Leite JP, Le Moullac-Vaidye B, Le Pendu J, Cruz Spano L. Loureiro Tonini MA, et al. Viruses. 2020 Sep 25;12(10):1084. doi: 10.3390/v12101084. Viruses. 2020. PMID: 32992989 Free PMC article.